p53 tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis
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p53 tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis
Abnormalities in the p53 tumor suppressor gene have been detected in rheumatoid arthritis (RA) and could contribute to the pathogenesis of chronic disease. To determine whether synoviocytes from invasive synovium in RA have an increased number of mutations compared with non-erosion synoviocytes, p53 cDNA subclones from fibroblast-like synoviocytes (FLS) derived from erosion and non-erosion site...
متن کاملSomatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium.
The factors that regulate the perpetuation and invasiveness of rheumatoid synovitis have been the subject of considerable inquiry, and the possibility that nonimmunologic defects can contribute to the disease has not been rigorously addressed. Using a mismatch detection system, we report that synovial tissue from the joints of severe chronic rheumatoid arthritis patients contain mutant p53 tran...
متن کامل1022 - Mutations of the P53 Tumor Suppressor Gene in Rheumatoid Arthritis Synovium
*Han, C Whan (A-Taejon St. Mary's Hospital); +**Kim, J Man; *Kim, W Yoo; *Kim, J Young; *Kim, H Kwan; *Ryu, J Duk; *Lee, K Won *Department of Orthopaedic Surgery, Taejon St. Mary's Hospital, Taejon, South Korea. +**Department of Orthopaedic Surgery, KangNam St. Mary's Hospital, Seoul, South Korea. Kang-Nam St. Mary's Hospital Department of Orthopaedic Surgery 505, Ban Po-Dong, Seo Cho-Ku Seoul,...
متن کاملAnalysis of p53 tumour suppressor gene somatic mutations in rheumatoid arthritis synovium.
OBJECTIVE In order to study the role of the p53 tumour suppressor gene in the proliferation of rheumatoid arthritis (RA) synovium, we analysed the mutation of p53 in the synovial fibroblast-like type B synoviocyte from RA patients. METHODS Synovial fibroblast-like type B synoviocytes were prepared from the synovial tissues from nine Japanese patients with RA. The p53 cDNA region from exons 4-...
متن کاملThe Synovium in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease targeting multiple joints. The synovium is the primary site of the inflammatory process, which if untreated leads to irreversible damage to the adjacent cartilage and bone. It is now well established that autoantibodies that are characteristic of RA, including rheumatoid factor (RF) and anti-citrulluninated protein antibodies (ACPA), are...
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ژورنال
عنوان ژورنال: Arthritis Res Ther
سال: 2005
ISSN: 1478-6354
DOI: 10.1186/ar1448